Erişkin Keçilerde Uzun Süreli Açlığın Galanin, Leptin, Tiroid Hormonları, İnsulin, Prolaktin, Büyüme Hormonu, Grelin ve Enerji Metabolizması ile İlgili Faktörler Üzerine Etkisi

Neda ESKANDARZADE, Mehdi SAEB, Saeed NAZIFI, Saeedeh SAEB, Nasrin KAZEMIPOUR, Maryam ANSARI-LARI
596 102

Öz


Açlık durumunda bazı hormonal bozukluklar gösterilmiş, ancak keçiler gibi geviş getiren hayvanlarda galaninin açlığa ya da endokrin fonksiyonlara uyumu iyi araştırılmamıştır. Mevcut çalışma erişkin keçilerde uzun sureli açlığın galanin, leptin, tiroid hormonları, insulin, prolaktin, büyüme hormonu, grelin ve HDL, kolestreol, β-hidroksibutirat, glukoz, NEFA, TG ve VLDL konsatrasyonları da dahil olmak üzere enerji metabolizması ile ilgili faktörler üzerine olan etkisini değerlendirmek için yürütülmüştür. 4-5 yaşları arasında, süt emzirmeyen ve gebe olmayan vücut kondisyon skoru 3 olan sekiz keçi rastgele olarak kontrol ve test gruplarına ayrıldı. Hayvanlara 10 günlük bir süre boyunca yemleme programına alıştırıldı. Deneysel işlem 20 gün uygulandı; bu süre içinde kontrol grup idame enerjisinin %120’sini aldı, test grubuna ise ilk 10 gün içinde idame enerjisinin %80’i verildi; diğer 10 gün boyunca ise idame enerjisinin %40’ı verildi. Yemleme programına alıştırmanın 10. gününde ve açlık başlamasından sonraki 2, 4, 10, 12, 14 ve 20. günlerde kan örnekleri alındı. Kan parametreleri standart işlemlere göre ölçüldü. Kontrol ve test grupları arasında kolesterol, fT3, T4, T3, büyüme hormonu, NEFA, insulin ve grelin yönünden bir farklılık görülmedi (P=0,05). Kontrol ve test grupları arasında galanin, leptin, fT4, HDL, glukoz, TG, VLDL ve prolaktin konsantrasyonlarında anlamlı farklılıklar vardı (P=0,05). Keçilerde uzun sureli açlığa uyumda galaninin rolü ve enerji dengesi kontrolü ya da endokrin fonksiyonları diğer türlerden farklılık göstermektedir.

Anahtar kelimeler


Uzun süreli açlık, galanin, leptin, biyokimyasal parametreler, enerji metabolizması, keçi

Tam metin:

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DOI: http://dx.doi.org/10.16988/iuvfd.2015.65233

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