Postoperatif radyoterapi uygulanan küçük hücreli dışı akciğer kanserli olgularda sağkalım üzerine etkili prognostik faktörlerin değerlendirilmesi

Süreyya SARIHAN, Cengiz GEBİTEKİN, Ahmet Sami BAYRAM, İlker ERCAN, Türkan EVRENSEL, Elif Ülker AKYILDIZ
403 121

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AMAÇ Postoperatif radyoterapi alan küçük hücreli dışı akciğer kanserli hastalarda sağkalım üzerindeki prognostik faktörler araştırıldı. GEREÇ VE YÖNTEM Ekim 1995-Ocak 2005 arasında 65 hasta ortanca 59 Gy (50-66.6 Gy) ile tedavi edildi. Klinik ve kategorik değişkenler incelendi. BULGULAR Çok değişkenli analizde; klinik N2 tutulumu, ilk nüksün beyin metastazı olması ve kemoterapi yokluğu (p=0.02, p=0.004, p=0.004) genel sağkalımı; patolojik lenf nodu tutulumu ve kemoterapi yokluğu (p=0.02, p=0.04) hastalıksız sağkalımı olumsuz etkilemiştir. Kategorik analizde; rezeksiyon tipi, pozitif cerrahi sınır ve N1 ile, sağ yerleşim, N1-e ve N2 ile sistematik nodal diseksiyon N1 ile ilişkili bulundu. Tutulmuş lenf nodu sayısı, N2 skip metastaz ile ve N1-10 tutulumu N1-e ile ilişkili bulundu. SONUÇ Metastatik lenf nodu varlığı kötü prognostik faktör olarak bulunmuş ve kemoterapi verilmesinin genel ve hastalıksız sağkalım oranlarını olumlu etkilediği görülmüştür.

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