Lokal ileri evre skuamöz hücreli baş ve boyun kanserinde sisplatinle eş zamanlı kemoradyoterapi: Yan etki ve uygulanabilirlik analizi

Beste Melek ATASOY, Faysal DANE, Murat SARI, Züleyha AKGÜN, Perran Fulden YUMUK, Nazım Serdar TURHAL, Ufuk ABACIOĞLU, Meriç ŞENGÖZ
422 171

Öz


AMAÇ Bu çalışmada, lokal ileri evre skuamöz hücreli baş ve boyun kanseri tanılı hastalarda eş zamanlı kemoradyoterapi (KRT) sırasında görülen yan etkiler analiz edilmiş, hasta, hastalık ve tedaviye bağlı faktörlerin eş zamanlı tedavinin tamamlanabilirliği üzerine etkisi incelenmiştir. GEREÇ VE YÖNTEM Kliniğimizde 2001-2007 yılları arasında konvansiyonel radyoterapi şemasıyla ortanca 70 Gy (50-73 Gy) tedavi görmüş 49'u primer, 16'sı adjuvan toplam 65 hasta çalışmaya dahil edildi. Hastalara eş zamanlı sisplatin 3 haftada bir 60-80 mg/m2 (n=57) ya da haftalık 40 mg/m2 (n=8) olarak uygulandı. BULGULAR Eş zamanlı kemoterapi hastaların % 4 6,1'inde planlanan şekilde uygulanabildi. Kemoterapi durdurma nedenleri arasında derece 3 ve üzeri yan etki (%41,6) yanında hasta reddi (%19,4) ve hekim kararı (%33,3) vardı. Radyoterapi öncesi Karnofsky Performans Durumu (KPS) ≥90 olan hastalarda eş zamanlı sisplatinin tamamlanma oranı %63,8 iken, bu oran KPS

Anahtar kelimeler


Karsinom, yassı hücreli,Baş ve boyun neoplazmları,Radyoterapi,Kemoterapi, adjuvan,Kombine tedavi uygulaması,Yan etkiler,Sisplatin,Fizibilite çalışmaları

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Referanslar


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