Radyoterapi uygulanmış oral kavite ve orofarenks kanserli hastalarda tedavi sonuçlarımız

Özlem Uruk ATAMAN, Zümre Arıcan ALICIKUŞ, Fadime AKMAN, Cenk ECEVİT, Sülen SARIOĞLU, Emel ADA, Ahmet Ömer İKİZ, Mehmet ŞEN, Münir KINAY
365 146

Öz


AMAÇ Ağustos 1991-Haziran 2003 tarihleri arasında Dokuz Eylül Baş-Boyun Kanserleri Grubu protokolüne uygun definitif (±kemoterapi) ve adjuvan radyoterapi uygulanan oral kavite (OK) ve orofarenks (OF) kanserli hastalarda tedavi sonuçları değerlendirildi. GEREÇ VE YÖNTEM Toplam 148 hasta (50 kadın, 98 erkek; medyan yaş 60; dağılım 24-90) (128 (%86) OK; 20 (%14) OF) değerlendirilmiştir. Evre dağılımı; evre-I: 15 (%10); evre-II: 14 (%9); evre-III: 35 (%24); evre-IV: 84 (%57) şeklindedir. Adjuvan radyoterapi 67 (%45); definitif radyoterapi 81 (%55) hastaya uygulanmıştır. Konkomitan boost tekniği 27 (%18); eş zamanlı sisplatin 23 (%16) hastaya uygulanmıştır. Definitif radyoterapide medyan doz 70 Gy (35-78), adjuvan radyoterapide 51 Gy (21- 70)'dir. BULGULAR Medyan izlem süresi 25 (3-158) aydır. Adjuvan radyoterapi uygulananlarda 2 ve 5 yıllık genel sağkalım (GSK) oranları sırasıyla %75; %61; hastalıksız aralık (HA) oranları ise %75; %64'dür. Definitif radyoterapi uygulanan OK hastalarında 2 ve 5 yıllık GSK oranları sırasıyla %48; %28; HA oranları ise %36; %24 iken OF kanserli hastalar için 2 ve 5 yıllık GSK oranları %54; %18; HA oranları ise %46; 46'dır. SONUÇ Özellikle yerel ileri evre OK ve OF tümörlerinde kombine tedavi yaklaşımları ile daha iyi sonuçlar alınmaktadır.

Anahtar kelimeler


Orofarinks neoplazmları,Ağız neoplazmları,Neoplazm evrelendirilmesi,Radyoterapi, adjuvan,Sağkalım oranı

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