Systemic Autoantibody Positivity is not Associated with the Presence of Oligoclonal Bands and Disability in Multiple Sclerosis
Objective: We aimed to determine the frequency of common systemic autoantibodies in patients with relapsing remitting multiple sclerosis (RRMS) and their association with the presence of oligoclonal bands (OCB) and disease severity. Materials and Methods: A total of 150 definite RRMS patients and 150 healthy controls with no autoimmune disease were enrolled and their sera were examined for the presence of autoantibodies. Results: The positivity rates for anti-thyroid peroxidase antibody (anti-TPO) (20%), anti-cardiolipin (ACA) IgG (22%) and ACA IgM (24%) antibodies were significantly higher than those of the healthy individuals (p<0.001). Age, gender, OCB positivity rates and average expanded disability status scale (EDSS) scores were comparable among RRMS patients with and without autoantibodies. Conclusion: Our findings suggest that serum autoantibodies are not significantly associated with disease severity or OCB formation and they are merely indicators of an increased susceptibility to autoimmune disease induction in MS patients.