THE TWO-WAY RELATIONSHIP BETWEEN OBESITY AND PERIODONTITIS-Obezite ve Periodontitis Arasındaki Karşılıklı İlişki

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Periodontitis and obesity are two chronic inflammatory diseases. Since obesity and periodontitis are associated with systemic inflammation, these two situations are linked by common pathophysiology. TNF-alfa and IL-6 are cytokines that are involved in the pathophysiology of both obesity and
periodontitis. The levels of these cytokines increase with obestiy and periodontitis. Resistin is produced by immune cells and therefore, is related to the activation of inflammatory processes. Increased resistin serum levels have been associated with periodontitis. Adipose tissues also secrete some antiinflammatory factors, such as adiponectin. Plasma levels of adiponectin are decreased in individuals who are obese, compared with persons who are normal weight. Furthermore, evidence suggests a trend toward decreased adiponectin serum levels and reduced adiponectin function in individuals with
periodontitis. In conclusion, periodontitis and obesity are diseases that are associated through various cytokines, proteins, vitamins, etc.

Keywords: Periodontitis, obesity, TNF-alpha, IL-6, resistin

Periodontitis ve obezite iki kronik enflamatuar hastalıktır. Obezite ve periodontitis sistemik enflamasyonla ilgili olduklarından bu iki hastalığın ortak patofizyolojiye sahip olduğu söylenebilir. TNF-alfa ve IL-6 obezite ve periodontitisin patofizyolojisinde yer alan sitokinlerdir. Bu sitokinlerin seviyeleri
obezite ve periodontitis ile birlikte artar. Resistin immun hücreler tarafından üretilir ve bu yüzden de enflamatuar sürecin aktivasyonunda yer alır. Resistinin pro-enflamatuar özellikleri TNF-alfa ve IL-6 salınımı ve adiponektinin anti-enflamatuar etkilerinin bozulmasıdır. Periodontitiste serumda resistin
seviyesi artmaktadır. Aynı zamanda adipoz dokular da adiponektin gibi bazı anti-enflamatuar faktörleri salgılamaktadır. Obez bireylerde normal ağırlıktaki bireylere göre plazmada azalmış adiponektin seviyeleri görülmektedir. Ayrıca bilimsel kanıtlar periodontitisli bireylerde serum adiponektin seviyesinin ve fonksiyonunun azaldığını göstermektedir. Sonuç olarak, periodontitis ve obezite çeşitli sitokinler, proteinler, ve vitaminler aracılığıyla birbirleri ile ilişkili iki hastalıktır.

Anahtar kelimeler: Periodontit, obezite, TNF-alfa, IL-6, rezistin


Periodontitis, obesity, TNF-alpha, IL-6, resistin

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Corresponding Author: Emine ÇİFCİBAŞI Department of Periodontology Faculty of Dentistry Istanbul University 34390 Capa-Istanbul, Turkey e-mail: Phone: 905307848581

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